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Craig Mello

Craig Mello

Keynote Speaker: Nobel Prize Winner, Known for His Research on RNA Interference; Distinguished Professor at the University of Massachusetts Medical School & Co-Director of the RNA Therapeutics Institute

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Craig Mello Biography

Dr. Craig Mello is the Blais University Chair in Molecular Medicine, Co-Director of the RNA Therapeutics Institute, and a Distinguished Professor at the University of Massachusetts Medical School. He holds a joint appointment as an Investigator at the Howard Hughes Medical Center. Dr. Mello is known for his research in collaboration with Dr. Andrew Z. Fire to discover RNA interference (RNAi), or the use of double-stranded RNA (dsRNA) to induce gene silencing. Dr. Mello and Dr. Fire were co-awarded the 2006 Nobel Prize in Physiology or Medicine for their work with RNAi in the model organism Caenorhabditis elegans. The role of dsRNA in gene silencing has been found to be a highly conserved mechanism in diverse species, including humans. Essentially, the injection of dsRNA silences a given gene by tricking the cell into destroying the gene's messenger RNA (mRNA) before it can form a functional protein. Scientists believe that this mechanism may have been developed hundreds of millions of years ago as a form of protection against invading viruses, which sometimes create dsRNA in their replication process. Today, the use of RNAi to silence genes has become a key molecular tool to understanding organismal development, gene function, and disease.

Dr. Mello's current research remains focused on the regulation and propagation of genetic information, investigating how proteins use short segments of genetic code (20-30 nucleotides of RNA) to recognize and regulate specific genes. These proteins, called Argonaute (AGO) proteins, use short segments of RNA code - "guide RNAs" - to facilitate chemical recognition through base-pairing with specific mRNAs present in the cell. Once an AGO guide RNA has bound to a target mRNA, the AGO can either destroy the mRNA or recruit other factors that regulate mRNA expression. This process has been shown to be highly conserved across plants and animals. The Mello lab uses C. elegans to investigate the role of AGO pathways in living organisms and in epigenetic inheritance, the inheritance of gene silencing patterns. Mello works to understand the basic mechanisms that underlie AGO pathways and how these pathways regulate and transmit information in order to answer the questions: Do AGOs function in a similar manner in humans? What is the impact of inheritance of epigenetic modifications on evolution, and could these mechanisms be important in maintaining the immortality and pluripotency of germline cells? Do similar systems function to maintain memories of gene expression in other tissues, and could these programs be important in human disease and aging?

Dr. Mello received his BS from Brown University in 1982, his PhD from Harvard University in 1990, and completed a post-doctoral fellowship at the Fred Hutchinson Cancer Research Center. Dr. Mello has received numerous awards for his research in addition to his Nobel Prize, including the 2003 Wiley Prize, the 2003 National Academy of Sciences Award in Molecular Biology, the 2004 Warren Triennial Prize, the 2005 Canada Gairdner International Award, and the 2005 Massry Prize. His articles appear in EMBO, Cell, and Nature, among other prominent journals.

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Craig Mello Videos

Informational Therapies: Ancient Mechanisms, New Medicines
Nobel Prize winner Craig Mello on how RNA science could change our lives

How do I book Craig Mello to speak at my event?

Our experienced booking agents have successfully helped clients around the world secure speakers like Craig Mello for speaking engagements, personal appearances, product endorsements, or corporate entertainment since 2002. Click the Check Schedule button above and complete the form on this page to check availability for Craig Mello, or call our office at 1.800.698.2536 to discuss your upcoming event. One of our experienced agents will be happy to help you get speaking fee information and check availability for Craig Mello or any other speaker of your choice.

How much does it cost to book Craig Mello for a speaking engagement?

Speaking fees for Craig Mello, or any other speakers and celebrities, are determined based on a number of factors and may change without notice. The estimated fee for a live event is Below $10,000. For the most current speaking fee to hire Craig Mello, click the Check Schedule button above and complete the form on this page, or call our office at 1.800.698.2536 to speak directly with an experienced booking agent.

What topics does Craig Mello speak about?

Craig Mello is a keynote speaker and industry expert who speaks on a wide range of topics such as Economy, Public Health, Science, Technology, STEM, Biology, Medicine, Professors, College and Academic.

Who is the agent for Craig Mello?

AAE Speakers Bureau has successfully secured keynote speakers like Craig Mello for clients worldwide since 2002. As a full-service speaker booking agency, we have access to virtually any speaker or celebrity in the world. Our agents are happy and able to submit an offer to the speaker or celebrity of your choice, letting you benefit from our reputation and long-standing relationships in the industry. Please click the Check Schedule button above and complete the form on this page including the details of your event, or call our office at 1.800.698.2536, and one of our agents will assist you to book Craig Mello for your next private or corporate function.

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AAE Speakers Bureau is a full-service speaker booking agency, meaning we can completely manage the speaker’s or celebrity’s engagement with your organization from the time of booking your speaker through the event’s completion. We provide all of the services you need to host Craig Mello or any other speaker of your choice, including offer negotiation, contractual assistance, accounting and billing, and event speaker travel and logistics services. When you book a speaker with us, we manage the process of hosting a speaker for you as an extension of your team. Our goal is to give our clients peace of mind and a best-in-class service experience when booking a speaker with us.

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Craig Mello is a keynote speaker and industry expert who speaks on a wide range of topics including Economy, Public Health and Science. The estimated speaking fee range to book Craig Mello for live events is Below $10,000. Please contact us for virtual event fees. Craig Mello can be booked for (private) corporate events, personal appearances, keynote speeches, or other performances. Similar motivational celebrity speakers are George Smoot, Dr. Joel Selanikio and Dean Kamen. Contact All American Speakers for ratings, reviews, videos and information on scheduling Craig Mello for an upcoming event.

Craig Mello Videos

Informational Therapies: Ancient Mechanisms, New Medicines
Nobel Prize winner Craig Mello on how RNA science could change our lives

Craig Mello Reviews

  • Dr. Mello was not only a big draw for us, but he delivered beyond our expectations. The audience was engaged thanks to Dr. Mello’s presentation style and informative talk.
    Charles River - May 12 2023

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